Dr. John O'Reilly - Curriculum Vitae
John P. O'Reilly, PhD
Assistant Professor
Department of Biological Sciences
Southeastern Louisiana University
SLU 10736
Hammond, Louisiana 70402
Tel: (985) 549.3536
Fax: (985) 549.3851
Email:
joreilly@selu.edu
EDUCATION
1997
Ph.D., Neurobiology, Department of Biology,
Yale University, New Haven, CT
Thesis Title:
Hypoxia in the Central Nervous System:
Electrophysiologic Responses and the Role of Na+ Channels.
1994
M.Phil., Department of Biology, Yale University,
New Haven, CT
1993
M.S., Department of Biology, Yale University, New
Haven, CT
1977
B.A., Biology, University of Virginia,
Charlottesville,VA
PRESENT POSITION
2008 present Associate Professor,
Southeastern Louisiana University, Hammond, LA
2003 2008Assistant Professor, Southeastern
Louisiana University, Hammond, LA
Teaching - Neurobiology with lab (undergraduate and graduate),
Animal Behavior with lab (undergraduate
and graduate), Animal Physiology with lab (undergraduate), Anatomy
& Physiology lecture & laboratory
(undergraduate), General Biology laboratory (undergraduate),
Biology of Sensory Systems (graduate),
Physiology of Homeostasis (graduate).
Research - structure-function analysis of slow inactivation in
voltage-gated Na+ channels (Navs).
PREVIOUS RESEARCH EXPERIENCE
1997 2002Postdoctoral Research Fellow,
Department of Anesthesia Research, Brigham & Women's
Hospital, Harvard Medical School,
Boston, MA
Research focused on understanding the relationship between
molecular structure and physiologic function in
voltage-gated sodium channels (Navs) using wild-type,
chimeric and mutant Navs from different species and tissues.
1991 1997Graduate Studies, Departments of
Biology, Neurobiology, Physiology, and Pediatrics
Yale University and Yale Medical
School, New Haven, CT
Electrophysiologic analysis of the response of neurons in the
central nervous system to oxygen deprivation
(hypoxia) which included the role of regional variations,
age-related differences, and other intrinsic and extrinsic
factors. Studies in other laboratories included restriction
mapping of olfactory-associated genes in Drosophila,
histological studies on muscle morphogenesis in Drosophila,
physiological studies of fever-induced temperature
regulation in rats, and neuropharmacologic studies on
synaptogenesis in frog.
1987 1991Research Associate, Department of
Biomedical Engineering, Johns Hopkins Medical School,
Baltimore, Maryland
Neuroanatomical and neurophysiological studies of the rat
autonomic nervous system using neuroanatomical
tracing, light and immunfluorescent microscopy, and in vivo
neurophysiologic recordings
1983 1986Research Associate, Department of Anatomy,
Georgetown University Medical School,
Washington, DC
Comparative neuroanatomical studies of the VIIIth cranial
nerve in fish and salamanders.
TEACHING EXPERIENCE
Southeastern Louisiana University, Hammond, LA
2008 present
Associate Professor, Department of Biological Sciences
2003 2008
Assistant Professor, Department of Biological Sciences
Neurobiology with lab (undergraduate and graduate)
once per year
Animal Behavior with lab (undergraduate and graduate) once
per year
Animal Physiology with lab (undergraduate) three terms
Anatomy & Physiology lecture & laboratory (undergraduate)
every semester
General Biology laboratory (undergraduate) every few years
Biology of Sensory Systems (graduate) every other year
Physiology of Homeostasis (graduate) every other year
Northeastern University, Boston, MA
2002 (2 terms)Invited Lecturer, Neurophysiology,
Physician Assistant Program
2000 2002 (4 terms) Instructor, Anatomy &
Physiology, Department of Biology
1999 (1 term) Instructor, General Biology for non-majors,
Department of Biology
Yale University, New Haven, CT
1995 1996 (2 terms) Lecturer, Laboratory for
Neurobiology (graduate & undergraduate)
1994 1995 (2 terms) Teaching Assistant, Laboratory for
Biology of Reproduction and Development
1992 1994 (3 terms) Teaching Assistant, Neurobiology
(lecture & laboratory, graduate & undergraduate)
1991 1992 (2 terms) Teaching Assistant, Lecture &
Laboratory for Introduction to Biology (for majors)
GRANTS AND FELLOWSHIPS
2008 2011Academic Research Enhancement Award
(R15-AREA), National Institutes of Health, $186,895
2005 2008Academic Research Enhancement Award
(R15-AREA), National Institutes of Health, $179,092
2008 2009 Faculty Development Grant, Southeastern Louisiana
University, $2000
2007 2008 Faculty Development Grant, Southeastern Louisiana
University, $2000
2006 2007 Faculty Development Grant, Southeastern Louisiana
University, $1000
2005 2006 Faculty Development Grant, Southeastern Louisiana
University, $1862
2004 2005 Faculty Development Grant, Southeastern Louisiana
University, $1800
2000 2003National Research Service Award, National
Institutes of Health, $126,844
1999 2000Postdoctoral Fellowship, American Heart
Association, New England Affiliate, $50,000
PROFESSIONAL AFFILIATIONS & ACTIVITIES
Biophysical Society
Society for Neuroscience
American Association for the Advancement of Science
Invited Reviewer, Journal of Neuorphysiology
Invited Reviewer, Experimental Brain Research
Invited Reviewer, Neuroscience Letters
Invited Reviewer, Pflugers Archives - European Journal of
Physiology
Invited Reviewer, Forensic Science International
Invited Reviewer, Biophysical Journal
Invited Reviewer, Journal of Physiology (London)
Invited Reviewer, Biochimica et Biophysica Acta - Biomembranes
PUBLICATIONS
Selected Peer-reviewed Research Articles
Chancey JW, Shockett PE, O'Reilly JP (2007) Relative
resistance to slow inactivation of human cardiacNa+
channel hNav1.5 is reversed by lysine or glutamine substitution at
V930 in D2-S6. American Journal ofPhysiology
Cell Physiology 293: C1895-C1905. PMID: 17928536
O'Reilly JP, Shockett PE (2006) Slow-inactivation induced
conformational change in domain 2-segment 6 of
cardiacNa+ channel. Biochemical and Biophysical
Research Communications 345: 59-66. PMID: 16674915
O'Reilly JP, Wang S-Y, Wang GK (2003)
Methanethiosulfonate-modification alters local anesthetic block
inrNav1.4 cysteine-substituted mutants S1276C and
L1280C. Journal of Membrane Biology. 193: 47-56.
PMID:12879165
O'Reilly JP, Wang S-Y, Wang GK (2001) Residue-specific effects on
slow inactivation at V787 in D2-S6 of Nav1.4sodium
channels. Biophysical Journal 81: 2100-2111. PMID:
11566781
Novotny EJ, Ariyan C, Mason GF, O'Reilly JP, Haddad GG, Behar KL
(2001) Differential increases in cerebral corticalglucose
metabolism during rat postnatal development is greater in vivo than
in vitro. Brain Research 888: 193-202.PMID:
11150475
O'Reilly JP, Wang S-Y, Wang GK (2000) A point mutation in domain 4
- segment 6 of rat skeletal muscle Na+channel produces
an atypical inactivation state. Biophysical Journal 78:
773-784. PMID: 10653790
Xia Y, Fung M, O'Reilly JP, Haddad GG (2000) Increased neuronal
excitability after long-term O2 deprivation ismediated mainly
by sodium channels. Brain Research: Molecular Brain Research
76(2):211-219. PMID:10762696
O'Reilly JP, Wang S-Y, Kallen RG, Wang GK (1999) Comparison of slow
inactivation in human heart and rat skeletalmuscle Na+
channel chimeras. Journal of Physiology (London) 515.1:
61-73. PMID: 9925878
O'Reilly JP, Cummins TR, Haddad GG (1997) Oxygen deprivation
inhibits Na+ current in hippocampal neurons viaprotein kinase
C. Journal of Physiology (London) 503.3: 479-488. PMID:
9379405
O'Reilly JP, Haddad GG (1996) Chronic hypoxia in vivo renders
neocortical neurons more vulnerable to subsequentacute
hypoxic stress. Brain Research 711: 203-210. PMID:
8680864
O'Reilly JP, Jiang C, Haddad GG (1995) Major differences in
response to graded hypoxia between hypoglossal and neocortical
neurons. Brain Research 683: 179-186. PMID: 7552353
Selected Published Abstracts and Presentations
O'Reilly JP, Shockett PE, Chancey JW (2009)
Structure-function analysis of slow inactivation in voltage-gated
Na+channels. Louisiana Academy of Sciences meeting.
Chancey JW, Shockett PE, O'Reilly JP (2007) Lysine substitution at
V930 in D2-S6 of hNav1.5 greatly enhancesslow inactivation.
2007 Biophysical Society Meeting Abstracts. Biophysical Journal
Supplement, 20a, 473-Pos.
O'Reilly JP, Wang S-Y, Wang GK (2002) MTSEA-modification of L1280C
in D3-S6 of rNav1.4 produces resistanceto local anesthetic
block similar to lysine-substitution in L1280K. Abstracts: Society
for Neuroscience 835.5.
O'Reilly JP, Wang S-Y, Wang GK (2001) Different amino acids at V787
in D2-S6 of rat skeletal muscle Na channelproduce opposite
effects on slow inactivation. Biophysical Society Abstract
692.
O'Reilly JP, Wang S-Y, Wang GK (1999) Altered kinetics with single
and double mutations in segment 6 of muscle Nachannel.
Biophysical Society Abstract 497.
O'Reilly JP, Wang S-Y, Wang GK (1998) Na channel slow
inactivation differs between human heart and rat
skeletalmuscle isoforms. Abstracts: Society for Neuroscience
427.7.
O'Reilly JP, Haddad GG (1996) Hypoxia reduces Na+ current in hippocampal neurons via a kinase mediated pathway.Abstracts: Society for Neuroscience 841.1.
O'Reilly JP, Schwartz ML, Haddad GG (1995) Adaptive mechanisms in
developing brain: II. Effect of chronic hypoxiaon neuronal
excitability. Annals of Neurology 38: 533.
Novotny EJ, Ariyan C, Akiyama Y, O'Reilly JP, Behar KL, Haddad GG
(1995) Comparison of the ontogeny of brainoxidative
metabolism in vivo vs in vitro: an NMR spectroscopy study.
Abstracts: Society for Neuroscience 656.6.
O'Reilly JP, Haddad GG (1995) Different responses of cortical and
brain stem neurons to graded hypoxia. AmericanJournal of
Respiratory and Critical Care Medicine 151(4): A633.51